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    HomePRODUCTSLife ScienceOsrhAAT Recombinant Human Alpha-1 Antitrypsin

    OsrhAAT Recombinant Human Alpha-1 Antitrypsin

    Cell Culture Grade

     

    • Source: Rice Grain (Oryza Sativa)

    • CAt No: HYC006M01

    • Appearance: White lyophilized powder 

    • Package: 10mg, 100mg

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    • Detailed Description
    • FAQ

    • Product Description

      Alphat-1 Antitrypsin (AAT) is a serine protease inhibitor. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. If it is deficiency, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children. OsrhAAT is derived from rice grain, which contains 384 amino acids with a molecular weight of 46.7kD. The rice endosperm platform makes the manufacture capability at hundreds of gram scales to meet your bioprocessing needs.

      Advantages of OsrHSA Application in Medical Devices

      Chemical Defined & Animal-Free;
      High Batch-to-Batch Consistancy;
      Stable Bulk Supply
      cGMP Manufactured
      DMF(No.29648)

      Why Select OsrHSA Over Yeast- and Plasma-Sourced Albumin

       Items OsrHSA (rice-derived) ScrHSA (yeast-derived)
      Safety Free of animal, Virus, Pathogene, low endotoxin Possible residual yeast cell wall components (such as B-glucan),additional removal of endotoxins required
      Post-translational modifications No glycosylation modification, structure identical to native HSA Glycosylation modification, Risk of inclusion formation requires reproducibility
      Production process Simple process with Three-step chromatography purification High-density fermentation is costly, with more complex production process
      Scale up Low-cost in rice cultivation
      Long-term stable storage in rice seeds
      Single-batch purification cycle: 24h
      Low immunogenicity, suitable for stem/primary cells, high batch
      consistency      		 High capital investment for fermentation equipmentSingle-batch production cycle:3-7 days
      Residual host proteins affect cell growth, batch difference exists
      Cell culture compatibility
      Regulation and ethics Comply with regulations and shorten the filing time, environmentally fri
      endly and sustainable      		 Microbial fermentation requires strict GMP control, Acceptance of genetically modified yeast
      varies by region

      Application

      Virus vaccine production
      Cell therapy & Gene therapy
      In vitro fertilization cryopreservation
      Regenerative medicine& Tissue storage
      Medical Source coating & Surgical sealants

      • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

        Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

      • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

        Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

      • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

        Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

      • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

        Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

    Tags:

    Recombinant Human Serum Albumin

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