HomePRODUCTSLife SciencerhlGF-1 LR3 Recombinant Human Insulin-like Growth Factor LR3

rhlGF-1 LR3 Recombinant Human Insulin-like Growth Factor LR3

Cell Culture Grade

 

• Source: Escherichia coli

• CAt No: HYC007M01, HYC007M02

• Appearance: White lyophilized powder 

• Package: 50ug, 1mg ,10mg

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  • Detailed Description
  • FAQ
  • Product Description

    Insulin-like growth factor-1 (IGF-1) is a hormone similar in molecular structure to insulin. It primarily functions through binding to its specific receptor, the insulin-like growth factor 1 receptor (IGF1R). IGF-1 is one of the most potent natural activators of the AKT signaling pathway, which stimulates cell growth and proliferation, and inhibits cell apoptosis. LR3 IGF-1 (Long Arg3 IGF-1) is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus. The LR3 IGF-1 has much higher stability and biological activity. 

    Advantages of OsrHSA Application in Medical Devices

    Chemical Defined & Animal-Free;
    High Batch-to-Batch Consistancy;
    Stable Bulk Supply
    cGMP Manufactured
    DMF(No.29648)

    Why Select OsrHSA Over Yeast- and Plasma-Sourced Albumin

     Items OsrHSA (rice-derived) ScrHSA (yeast-derived)
    Safety Free of animal, Virus, Pathogene, low endotoxin Possible residual yeast cell wall components (such as B-glucan),additional removal of endotoxins required
    Post-translational modifications No glycosylation modification, structure identical to native HSA Glycosylation modification, Risk of inclusion formation requires reproducibility
    Production process Simple process with Three-step chromatography purification High-density fermentation is costly, with more complex production process
    Scale up Low-cost in rice cultivation
    Long-term stable storage in rice seeds
    Single-batch purification cycle: 24h
    Low immunogenicity, suitable for stem/primary cells, high batch
    consistency
    High capital investment for fermentation equipmentSingle-batch production cycle:3-7 days
    Residual host proteins affect cell growth, batch difference exists
    Cell culture compatibility
    Regulation and ethics Comply with regulations and shorten the filing time, environmentally fri
    endly and sustainable
    Microbial fermentation requires strict GMP control, Acceptance of genetically modified yeast
    varies by region

    Application

    Virus vaccine production
    Cell therapy & Gene therapy
    In vitro fertilization cryopreservation
    Regenerative medicine& Tissue storage
    Medical Source coating & Surgical sealants

    • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

      Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

    • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

      Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

    • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

      Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

    • Do you have any comparison data between your OsrHSA and plasma derived human serum albumin (pHSA)? Is there any difference?

      Yes, we do. From our comparative test, OsrHSA is structurelly and biochemically equivalent to pHSA, and functions equivalently to pHSA in terms of binding capacity and promotion of cell growth. In addition, OsrHSA displays the same immunogenicity as pHSA.

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